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Biomaterials for contact lens and artificial cornea
#1
Good morning,

I hope that you all can help me out. I am doing some studies on contact lens and artificial corneas. I need to know what biomaterials are typically used for such applications.

I understand that the important characteristics include mechanical properties, oxygen
permeability, transparency and surface wettability.

If anyone can help me to learn the most commonly used materials that would help me greatly.

Thank you in advance, Aldo [img]style_emoticons/<#EMO_DIR#>/unsure.gif[/img] [img]style_emoticons/<#EMO_DIR#>/unsure.gif[/img]
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#2
hi aldo,

this information from wikipedia might help you:

<!--quoteo-->QUOTE<!--quotec-->
<b>Types of contact lenses - By constructional material</b>

The first contact lenses were made of glass, which caused eye irritation, and so were not able to be worn for extended periods of time. But when Dr. William Feinbloom introduced lenses made from polymethyl methacrylate (PMMA or Perspex/Plexiglas), contacts become much more convenient. These PMMA lenses are commonly referred to as "hard" lenses (this term is not used for other types of contacts).

However, PMMA lenses have their own side effects: no oxygen is transmitted through the lens to the cornea, which can cause a number of adverse clinical events. In the late 1970s, and through the 1980s and 1990s, improved rigid materials — which were also oxygen-permeable — were developed. Collectively, these polymers are referred to as 'rigid gas permeable' or 'RGP' materials or lenses.

Rigid lenses offer a number of unique properties. In effect, the lens is able to replace the natural shape of the cornea with a new refracting surface. This means that a regular (spherical) rigid contact lens can provide good level of vision in people who have astigmatism or distorted corneal shapes as with keratoconus.

Whilst rigid lenses have been around for about 120 years, soft lenses are a much more recent development. The principal breakthrough in soft lenses made by Otto Wichterle led to the launch of the first soft (hydrogel) lenses in some countries in the 1960s and the approval of the 'Soflens' material (polymacon) by the United States FDA in 1971. Soft lenses are immediately comfortable, while rigid lenses require a period of adaptation before full comfort is achieved. The polymers from which soft lenses are manufactured improved over the next 25 years, primarily in terms of increasing the oxygen permeability by varying the ingredients making up the polymers.

A small number of hybrid rigid/soft lenses exist. An alternative technique is piggybacking of contact lenses, a smaller, rigid lens being mounted atop a larger, soft lens. This is done for a variety of clinical situations where a single lens will not provide the optical power, fitting characteristics, or comfort required.

In 1999, 'silicone hydrogels' became available. Silicone hydrogels have both the extremely high oxygen permeability of silicone and the comfort and clinical performance of the conventional hydrogels. These lenses were initially advocated primarily for extended (overnight) wear, although more recently daily (no overnight) wear silicone hydrogels have been launched.

While it provides the oxygen permeability, the silicone also makes the lens surface highly hydrophobic and less "wettable." This frequently results in discomfort and dryness during lens wear. In order to compensate for the hydrophobicity, hydrogels are added (hence the name "silicone hydrogels") to make the lenses more hydrophilic. However the lens surface may still remain hydrophobic. Hence some of the lenses undergo surface modification processes which cover the hydrophobic sites of silicone. Some other lens types incorporate internal rewetting agents to make the lens surface hydrophilic.<!--QuoteEnd--><!--QuoteEEnd-->

http://en.wikipedia.org/wiki/Contact_lens#...tional_material
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