Biomaterials Patents - 2000 | 2001
- NEW METHOD OF IMPLANTING ARTIFICIAL BONE TO COMBINE CONTROL OF BIOCOMPATIBILITY IN SURFACE OF BIOMATERIAL BY POLISHING SURFACE AND STICKING OF CULTURED OSTEOBLASTS
- COMPOSITION OF MATTER FOR BIOMATERIAL AND HARDENED BODY THEREOF
- COMPLEX BIOMATERIAL
- COMPOSITE BIOMATERIAL
- COMPOSITE FOR BIOMATERIAL AND ITS MANUFACTURING METHOD
- CALCIUM PHOSPHATE-TITANIUM-BASED COMPOSITE MATERIAL FOR BIOMATERIAL AND METHOD OF MANUFACTURING THE SAME
- CALCIUM PHOSPHATE COATED ZIRCONIA BIOMATERIAL AND ITS PREPARATION
- MEDICAL APPLIANCE COMPOSED OF Ti-Zr ALLOY
NEW METHOD OF IMPLANTING ARTIFICIAL BONE TO COMBINE CONTROL OF BIOCOMPATIBILITY IN SURFACE OF BIOMATERIAL BY POLISHING SURFACE AND STICKING OF CULTURED OSTEOBLASTS
| (11)Publication number : | 2001-333974 |
| (43)Date of publication of application : | 04.12.2001 |
| (51)Int.CI. A61L 27/00 A61F 2/32 |
| (21)Application number : | 2000-155116 | (71)Applicant : | NATL INST OF ADVANCED INDUSTRIAL SCIENCE & TECHNOLOGY METI |
| (22)Date of filing : | 25.05.2000 | (72)Inventor : | FUJISHIRO
YOSHINOBU OYAMA MASAMIZU KOKUBU SHOICHI KAJI KOJI |
| Abstract: PROBLEM TO BE SOLVED: To provide an artificial bone material that is highly biocompatible by sticking cultured osteoblasts to its surface. SOLUTION: The artificial bone material is highly biocompatible by sticking cultured osteoblasts to its surface. Feature of the artificial bone material is to be stuck with the osteoblasts to surface of the material by impregnating the culture medium of the osteoblasts obtained from cultured bony tissue into a material that mainly consists of calcium phosphate ceramic glassily polished by polishing surface. |
COMPOSITION OF MATTER FOR BIOMATERIAL AND HARDENED BODY THEREOF
| (11)Publication number : | 2001-314497 |
| (43)Date of publication of application : | 13.11.2001 |
| (51)Int.CI. A61L 27/00 A61C 8/00 A61K 6/033 C04B 14/28 C04B 24/38 C04B 28/34 C04B 38/00 // C04B103:10 C04B111:00 |
| (21)Application number : | 2000-133911 | (71)Applicant : | UNIV NIHON |
| (22)Date of filing : | 02.05.2000 | (72)Inventor : | YASUE TAKASHI |
 Abstract:PROBLEM TO BE SOLVED: To provide a biomaterial made of a composition of matter and hardened porous body thereof, which is big in the diameter of a pore and the interval between the pores and has a high strength. SOLUTION: The composition of matter for biomaterial and the hardened porous body thereof contains at least calcium phosphate compound which has a hydration hardening property, calcium carbonate and water. |
COMPLEX BIOMATERIAL
| (11)Publication number : | 2001-309970 |
| (43)Date of publication of application : | 06.11.2001 |
| (51)Int.CI. A61L 27/00 A61K 6/00 A61K 6/033 A61L 24/00 |
| (21)Application number : | 2000-130997 | (71)Applicant : | KYOCERA CORP |
| (22)Date of filing : | 28.04.2000 | (72)Inventor : | MARUYAMA HIROSHI |
 Abstract:PROBLEM TO BE SOLVED: To provide a complex biomaterial the major material of which is apatite that is high in dimensional accuracy, is prepared easily, and is raised in strength and toughness. SOLUTION: Inorganic fibers 3 of woven or nonwoven fabric is filled in a hydration-hardened matrix 2 the major component of which is apatite. The complex biomaterial 1 showing nonlinear fracture behavior against ≤5% mechanical distortion in the four-point bending test based on JISR1601 is used as artificial bone or artificial tooth root. |
COMPOSITE BIOMATERIAL
| (11)Publication number : | 2001-276209 |
| (43)Date of publication of application : | 09.10.2001 |
| (51)Int.CI.
A61L 27/00 A61C 8/00 A61C 13/00 A61K 6/00 A61K 6/033 A61L 24/00 B28B 1/14 C04B 28/34 //(C04B 28/34 C04B 14:30 C04B 14:32 C04B 14:38 C04B 14:36 ) |
| (21)Application number : | 2000-092190 | (71)Applicant : | KYOCERA CORP |
| (22)Date of filing : | 29.03.2000 | (72)Inventor : | MARUYAMA HIROSHI |
 Abstract:PROBLEM TO BE SOLVED: To obtain a composite biomaterial which can be manufactured easily with high dimensional accuracy, is improved in strength and thoughness, and is composed mainly of apatite. SOLUTION: This composite biomaterial 1 contains an inorganic filler 3 containing at least one kind of ceramic selected from among alumina, mullite, silicon nitride, zirconia, and silicon carbide and inorganic fibers 4 in a hydration- curing matrix 2 composed mainly of apatite. The biomaterial 1 is used for artificial bones and roots of teeth. |
COMPOSITE FOR BIOMATERIAL AND ITS MANUFACTURING METHOD
| (11)Publication number : | 2001-276207 |
| (43)Date of publication of application : | 09.10.2001 |
| (51)Int.CI. A61L 27/00 |
| (21)Application number : | 2000-092249 | (71)Applicant : | JAPAN
SCIENCE & TECHNOLOGY CORP NATIONAL INSTITUTE FOR MATERIALS SCIENCE NITTA GELATIN INC |
| (22)Date of filing : | 29.03.2000 | (72)Inventor : | TANAKA
JUNZO KIKUCHI MASANORI NAKATANI SHINICHI BANDAI YOSHINOBU HIRAOKA YOSUKE |
| Abstract: PROBLEM TO BE SOLVED: To obtain a composite for biomaterial which has a high strength and physical properties approximating to those of the bones of living things and exhibits a superior resistance to degradation when the material is implanted in an organism and a method for manufacturing the material. SOLUTION: This composite for biomaterial is obtained by performing the coprecipitation of calcium phosphate and collagen by mixing an aqueous solution of phosphoric acid containing the collagen and an aqueous solution containing a calcium slat with each other, and then, press-molding the obtained precipitated. At this time, the precipitate is crosslinked, when press-molding or after press- molding, for obtaining the composite for biomaterial. |
CALCIUM PHOSPHATE-TITANIUM-BASED COMPOSITE MATERIAL FOR BIOMATERIAL AND METHOD OF MANUFACTURING THE SAME
| (11)Publication number : | 2001-259017 |
| (43)Date of publication of application : | 25.09.2001 |
| (51)Int.CI.
A61L 27/00 A61C 8/00 A61F 2/28 B22F 3/105 C04B 35/447 C04B 35/64 C22C 1/05 C22C 14/00 C22C 29/00 C22C 32/00 |
| (21)Application number : | 2000-121766 | (71)Applicant : | WATARI
FUMIO OMORI MAMORU |
| (22)Date of filing : | 19.03.2000 | (72)Inventor : | WATARI
FUMIO OMORI MAMORU HIRAI TOSHIO |
 Abstract:PROBLEM TO BE SOLVED: To solve such problems that a composite material of hydroxy apatite and titanium which is a kind of calcium phosphate has low fracture toughness, easy tendency to fracture and the graded concentration material of the same system has the easy tendency to the occurrence of delayed decomposition and instability. SOLUTION: Sufficient sintering is executed without the progression of the decomposition of the apatite even in the coexistence of the titanium by the promotion of a sintering effect and the lowering of a sintering temperature by using a discharge plasma sintering method, thereby, the dense calcium phosphate-titanium composite material for the biomaterial having the high fracture toughness and the graded concentration material free of the delayed decomposition can be manufactured. Accordingly, the stable and reliable biomaterial having bioaffinity and mechanical characteristics in combination can be manufactured. |
CALCIUM PHOSPHATE COATED ZIRCONIA BIOMATERIAL AND ITS PREPARATION
| (11)Publication number : | 2001-231849 |
| (43)Date of publication of application : | 28.08.2001 |
| (51)Int.CI. A61L 27/00 A61K 6/033 A61K 6/04 C01B 25/32 C04B 41/87 |
| (21)Application number : | 2000-047914 | (71)Applicant : | MATSUSHITA
ELECTRIC WORKS LTD AIZAWA MAMORU |
| (22)Date of filing : | 24.02.2000 | (72)Inventor : | NAWA
MASAHIRO AIZAWA MAMORU |
 Abstract:PROBLEM TO BE SOLVED: To obtain a calcium phosphate coated zirconia biomaterial having a sufficient mechanical property, high strength and toughness, and superior bioactive function, and to provide a method for preparing the calcium phosphate coated zirconia biomaterial allowing high-degree control of the configuaration, composition and thickness of the calcium phosphate coat to be formed. SOLUTION: The calcium phosphate coated zirconia biomaterial comprises a bioactive coating 3 composed of porous calcium phosphate having opening pores 2 of size 100-500 μm and formed on the surface of a substrate 1 containing zirconia. The method for its preparation comprises the process of accumulating hollow calcium phosphate flocks on the surface of the substrate 1 containing zirconia and the process of sintering the accumulated hollow calcium phosphate flocks to form the bioactive coating 3, composed of the porous calcium phosphate having the opening pores 2 of size 100-500 μm, on the surface of the substrate 1. |
MEDICAL APPLIANCE COMPOSED OF Ti-Zr ALLOY
| (11)Publication number : | 2001-003126 |
| (43)Date of publication of application : | 09.01.2001 |
| (51)Int.CI. C22C 14/00 A61C 8/00 A61L 27/00 A61L 31/00 C22C 16/00 |
| (21)Application number : | 11-375057 | (71)Applicant : | TERUMO
CORP NIPPON SOZAI KK INOUE AKIHISA |
| (22)Date of filing : | 28.12.1999 | (72)Inventor : | CHIYOU
TOU SATO KAZUYA KUROSAKA TAKASHI OGATA YUJI O SHINBIN KANEKO TAKASHI KASORI YUTAKA |
| (30)Priority | |||||
| Priority number : | 11116225 | Priority date : | 23.04.1999 | Priority country : | JP |
| Abstract: PROBLEM TO BE SOLVED: To provide excellent biocompatibility required of a biomaterial to be implanted in a living body over a long period by incorporating specific percentages of Ti, Zr, Nb, and Ta and regulating the ratio of Zr to Ti by mass and the ratio of Nb to Ta by mass to values in specific ranges, respectively. SOLUTION: A medical appliance, composed of a Ti-Zr alloy, having a composition which consists of, by mass, 25-50%, desirably 30-40% Ti, 25-60%, desirably 25-45% Zr, 5-30%, desirably 10-15% Nb, and 5-40%, desirably 15-25% Ta and in which the ratio of Zr to Ti by mass is regulated to 0.5-1.5, desirably 0.8-1.2, and also the ratio of Nb to Ta by mass is regulated to 0.125-1.5, desirably 0.5-1.0, is produced. Moreover, a part of Zr can be substituted by Sn and the content of Sn is regulated so that it comprises 5-10 mass % of the whole alloy; at least either of Nb and Ta can be substituted by one or more elements among Pd, Pt, and Au and the content of one or more elements among Pd, Pt, and Au is regulated so that it comprises 0.01-5 mass % of the whole alloy. |